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TargetTranslocator protein
LigandBDBM50335266
Substrate/Competitorn/a
Meas. Tech.ChEMBL_702766 (CHEMBL1655209)
Ki 23.7±n/a nM
Citation Pike, VWTaliani, SLohith, TGOwen, DRPugliesi, IDa Pozzo, EHong, JZoghbi, SSGunn, RNParker, CARabiner, EAFujita, MInnis, RBMartini, CDa Settimo, F Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands. J Med Chem54:366-73 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50335266
n/a
NameBDBM50335266
Synonyms:2-(5-fluoro-1-methyl-2-phenyl-1H-indol-3-yl)-2-oxo-N,N-dipropylacetamide | CHEMBL1651232
TypeSmall organic molecule
Emp. Form.C23H25FN2O2
Mol. Mass.380.4552
SMILESCCCN(CCC)C(=O)C(=O)c1c(-c2ccccc2)n(C)c2ccc(F)cc12
Structure
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