Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProcathepsin L
LigandBDBM50335277
Substrate/Competitorn/a
Meas. Tech.ChEMBL_702782 (CHEMBL1655225)
Ki 2.6±n/a nM
Citation Frizler, MLohr, FFurtmann, NKläs, JGütschow, M Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors. J Med Chem54:396-400 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50335277
n/a
NameBDBM50335277
Synonyms:CHEMBL1651351 | N-(Benzyloxycarbonyl)-isoleucyl-methylazalanine-nitrile
TypeSmall organic molecule
Emp. Form.C17H24N4O3
Mol. Mass.332.3975
SMILESCC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N(C)N(C)C#N |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: