Reaction Details |
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Target | Cathepsin B |
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Ligand | BDBM50335282 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_702785 (CHEMBL1655228) |
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Ki | 2.8±n/a nM |
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Citation | Frizler, M; Lohr, F; Furtmann, N; Kläs, J; Gütschow, M Structural optimization of azadipeptide nitriles strongly increases association rates and allows the development of selective cathepsin inhibitors. J Med Chem54:396-400 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin B |
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Name: | Cathepsin B |
Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
Type: | Enzyme |
Mol. Mass.: | 37819.69 |
Organism: | Homo sapiens (Human) |
Description: | gi_63102437 |
Residue: | 339 |
Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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BDBM50335282 |
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n/a |
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Name | BDBM50335282 |
Synonyms: | CHEMBL1651356 | N-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzylcarbamoyl]-leucyl-methylazaalanine-nitrile | acs.jmedchem.1c00409_ST.405 |
Type | Small organic molecule |
Emp. Form. | C20H27N7O3 |
Mol. Mass. | 413.4735 |
SMILES | CC(C)C[C@H](NC(=O)NCc1ccc(cc1)-c1noc(C)n1)C(=O)N(C)N(C)C#N |r| |
Structure |
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