| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM50335326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701579 (CHEMBL1656338) |
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| IC50 | 34000±n/a nM |
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| Citation |  Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; von der Saal, W; Limberg, A; Georges, G; Engh, RA; Goller, B; Rueger, P; Rueth, M Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. J Med Chem54:312-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM50335326 |
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| n/a |
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| Name | BDBM50335326 |
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| Synonyms: | CHEMBL1651491 | N-(4-((4-(1H-pyrazol-3-ylamino)-1-oxophthalazin-2(1H)-yl)methyl)phenyl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18N6O2 |
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| Mol. Mass. | 374.3959 |
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| SMILES | CC(=O)Nc1ccc(Cn2nc(Nc3ccn[nH]3)c3ccccc3c2=O)cc1 |
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| Structure | 
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