| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM50249210 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_701578 (CHEMBL1656337) |
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| IC50 | 66±n/a nM |
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| Citation |  Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; von der Saal, W; Limberg, A; Georges, G; Engh, RA; Goller, B; Rueger, P; Rueth, M Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. J Med Chem54:312-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM50249210 |
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| n/a |
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| Name | BDBM50249210 |
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| Synonyms: | 4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2,2,2-trifluoroethyl)phthalazin-1(2H)-one | CHEMBL470718 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12F3N5O |
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| Mol. Mass. | 323.2732 |
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| SMILES | Cc1cc(Nc2nn(CC(F)(F)F)c(=O)c3ccccc23)[nH]n1 |
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| Structure | 
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