Reaction Details |
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Target | Tyrosine 3-monooxygenase |
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Ligand | BDBM37633 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_714884 (CHEMBL1663830) |
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IC50 | 1.4±n/a nM |
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Citation | Hayashi, S; Nakata, E; Morita, A; Mizuno, K; Yamamura, K; Kato, A; Ohashi, K Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity rela Bioorg Med Chem18:7675-99 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine 3-monooxygenase |
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Name: | Tyrosine 3-monooxygenase |
Synonyms: | TY3H_RAT | Th | Tyrosine 3-hydroxylase | Tyrosine 3-monooxygenase |
Type: | PROTEIN |
Mol. Mass.: | 55960.29 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_714884 |
Residue: | 498 |
Sequence: | MPTPSAPSPQPKGFRRAVSEQDAKQAEAVTSPRFIGRRQSLIEDARKEREAAAAAAAAAV
ASSEPGNPLEAVVFEERDGNAVLNLLFSLRGTKPSSLSRAVKVFETFEAKIHHLETRPAQ
RPLAGSPHLEYFVRFEVPSGDLAALLSSVRRVSDDVRSAREDKVPWFPRKVSELDKCHHL
VTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTL
KGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARDF
LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS
DEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAV
QPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSL
EGVQDELHTLAHALSAIS
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BDBM37633 |
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n/a |
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Name | BDBM37633 |
Synonyms: | (2S)-2-amino-3-(4-hydroxy-3-iodo-phenyl)propionic acid | (2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | (2S)-2-azanyl-3-(3-iodanyl-4-oxidanyl-phenyl)propanoic acid | 3-IODO-L-TYROSINE | 3-Iodo-L-tyrosine (I-Tyr) | MLS000069664 | Monoiodotyrosine | SMR000059143 | cid_439744 |
Type | Small organic molecule |
Emp. Form. | C9H10INO3 |
Mol. Mass. | 307.0851 |
SMILES | N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O |
Structure |
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