| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen-related receptor gamma |
|---|
| Ligand | BDBM50336730 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_718357 (CHEMBL1679777) |
|---|
| IC50 | 2800±n/a nM |
|---|
| Citation |  Patch, RJ; Searle, LL; Kim, AJ; De, D; Zhu, X; Askari, HB; O'Neill, JC; Abad, MC; Rentzeperis, D; Liu, J; Kemmerer, M; Lin, L; Kasturi, J; Geisler, JG; Lenhard, JM; Player, MR; Gaul, MD Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents. J Med Chem54:788-808 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen-related receptor gamma |
|---|
| Name: | Estrogen-related receptor gamma |
|---|
| Synonyms: | ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51305.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1501351 |
|---|
| Residue: | 458 |
|---|
| Sequence: | MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
|
|
|
|---|
| BDBM50336730 |
|---|
| n/a |
|---|
| Name | BDBM50336730 |
|---|
| Synonyms: | 4-[4-(2,4-Dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile | CHEMBL1671971 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H11F3N2O4S |
|---|
| Mol. Mass. | 420.362 |
|---|
| SMILES | COc1cc(C=C2SC(O)=NC2=O)ccc1Oc1ccc(cc1C(F)(F)F)C#N |w:5.4,c:9| |
|---|
| Structure | 
|
|---|
Search and Browse
