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TargetPurinergic, P2X2
LigandBDBM50336767
Substrate/Competitorn/a
Meas. Tech.ChEMBL_718656
IC50 2000±n/a nM
Citation Baqi YHausmann RRosefort CRettinger JSchmalzing GMüller CE Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor. J Med Chem 54:817-30 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Purinergic, P2X2
Name:Purinergic, P2X2
Synonyms:ATP receptor | P2X purinoceptor 2 | P2X2 | P2X2/P2X3 receptor | Purinergic receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:52625.55
Organism:RAT
Description:Purinergic, P2X2 0 RAT::P49653
Residue:472
Sequence:
MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSET
GPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVH
SSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMA
PNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENF
TELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGT
TTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNK
LYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAEL
PLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL
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  Blast E-value cutoff:
BDBM50336767
n/a
NameBDBM50336767
Synonyms:CHEMBL257495 | PSB-716 | sodium 1-amino-4-(2-methoxyphenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
TypeSmall organic molecule
Emp. Form.C21H15N2O6S
Mol. Mass.423.419
SMILESCOc1ccccc1Nc1cc(c(N)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O
Structure
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