| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50015142 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_718471 (CHEMBL1680135) |
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| IC50 | 4000±n/a nM |
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| Citation |  Fass, DM; Shah, R; Ghosh, B; Hennig, K; Norton, S; Zhao, WN; Reis, SA; Klein, PS; Mazitschek, R; Maglathlin, RL; Lewis, TA; Haggarty, SJ Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin. ACS Med Chem Lett2:39-42 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50015142 |
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| n/a |
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| Name | BDBM50015142 |
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| Synonyms: | 4-Phenylbutyrohydroxamic acid | CHEMBL55895 | N-Hydroxy-4-phenyl-butyramide |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13NO2 |
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| Mol. Mass. | 179.2157 |
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| SMILES | ONC(=O)CCCc1ccccc1 |
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| Structure | 
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