| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50338491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_728313 (CHEMBL1687573) |
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| Ki | 14.5±n/a nM |
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| Citation |  Jiang, Y; Hansen, TV Isatin 1,2,3-triazoles as potent inhibitors against caspase-3. Bioorg Med Chem Lett21:1626-9 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50338491 |
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| n/a |
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| Name | BDBM50338491 |
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| Synonyms: | (S)-1-((1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(methoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione | CHEMBL1683178 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N5O7S |
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| Mol. Mass. | 539.56 |
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| SMILES | COC[C@@H]1CCCN1S(=O)(=O)c1ccc2N(Cc3cn(nn3)-c3ccc4OCCOc4c3)C(=O)C(=O)c2c1 |r| |
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| Structure | 
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