| Reaction Details |
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 | Report a problem with these data |
| Target | Pleiotropic ABC efflux transporter of multiple drugs |
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| Ligand | BDBM78436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_730212 (CHEMBL1696307) |
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| IC50 | 2300±n/a nM |
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| Citation |  Kolaczkowski, M; Kolaczkowska, A; Motohashi, N; Michalak, K New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters. Antimicrob Agents Chemother53:1516-27 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pleiotropic ABC efflux transporter of multiple drugs |
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| Name: | Pleiotropic ABC efflux transporter of multiple drugs |
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| Synonyms: | LEM1 | PDR5 | PDR5_YEAST | Pleiotropic drug resistance protein 5 | STS1 | Suppressor of toxicity of sporidesmin | YDR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 170453.87 |
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| Organism: | Saccharomyces cerevisiae S288c |
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| Description: | ChEMBL_730212 |
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| Residue: | 1511 |
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| Sequence: | MPEAKLNNNVNDVTSYSSASSSTENAADLHNYNGFDEHTEARIQKLARTLTAQSMQNSTQ
SAPNKSDAQSIFSSGVEGVNPIFSDPEAPGYDPKLDPNSENFSSAAWVKNMAHLSAADPD
FYKPYSLGCAWKNLSASGASADVAYQSTVVNIPYKILKSGLRKFQRSKETNTFQILKPMD
GCLNPGELLVVLGRPGSGCTTLLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVV
YNAEADVHLPHLTVFETLVTVARLKTPQNRIKGVDRESYANHLAEVAMATYGLSHTRNTK
VGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISNT
SATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLTS
VTSPSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVDQRLLNDDEASREAIK
EAHIAKQSKRARPSSPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSM
FFKIMKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADA
FASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSHLFRCVGSLT
KTLSEAMVPASMLLLALSMYTGFAIPKKKILRWSKWIWYINPLAYLFESLLINEFHGIKF
PCAEYVPRGPAYANISSTESVCTVVGAVPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMA
YVVFFFFVYLFLCEYNEGAKQKGEILVFPRSIVKRMKKRGVLTEKNANDPENVGERSDLS
SDRKMLQESSEEESDTYGEIGLSKSEAIFHWRNLCYEVQIKAETRRILNNVDGWVKPGTL
TALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPRDKSFPRSIGYCQQQDLHLKTAT
VRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGEGLNVEQRKRLTI
GVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDR
LLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQD
YYEVWRNSEEYRAVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIRLFQQYW
RSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQNQMLAVFMFTVIFNPILQQYLPSFV
QQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYFIYYYPIGFYSNASAAGQL
HERGALFWLFSCAFYVYVGSMGLLVISFNQVAESAANLASLLFTMSLSFCGVMTTPSAMP
RFWIFMYRVSPLTYFIQALLAVGVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAKT
GYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLAR
VPKKNGKLSKK
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| BDBM78436 |
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| n/a |
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| Name | BDBM78436 |
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| Synonyms: | 2-(ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine;2-hydroxybutanedioic acid | 2-(ethylthio)-10-[3-(4-methylpiperazino)propyl]phenothiazine;malic acid | 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;2-hydroxybutanedioic acid | 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;2-oxidanylbutanedioic acid | MLS002154140 | SMR001233447 | THIETHYLPERAZINE | Thiethylperazine malate | cid_3085006 | med.21724, Compound Thiethylperazine |
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| Type | Small organic molecule |
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| Emp. Form. | C22H29N3S2 |
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| Mol. Mass. | 399.616 |
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| SMILES | CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1 |
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| Structure | 
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