| Reaction Details |
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 | Report a problem with these data |
| Target | Pleiotropic ABC efflux transporter of multiple drugs |
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| Ligand | BDBM50339134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_730212 (CHEMBL1696307) |
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| IC50 | 3200±n/a nM |
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| Citation |  Kolaczkowski, M; Kolaczkowska, A; Motohashi, N; Michalak, K New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters. Antimicrob Agents Chemother53:1516-27 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pleiotropic ABC efflux transporter of multiple drugs |
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| Name: | Pleiotropic ABC efflux transporter of multiple drugs |
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| Synonyms: | LEM1 | PDR5 | PDR5_YEAST | Pleiotropic drug resistance protein 5 | STS1 | Suppressor of toxicity of sporidesmin | YDR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 170453.87 |
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| Organism: | Saccharomyces cerevisiae S288c |
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| Description: | ChEMBL_730212 |
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| Residue: | 1511 |
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| Sequence: | MPEAKLNNNVNDVTSYSSASSSTENAADLHNYNGFDEHTEARIQKLARTLTAQSMQNSTQ
SAPNKSDAQSIFSSGVEGVNPIFSDPEAPGYDPKLDPNSENFSSAAWVKNMAHLSAADPD
FYKPYSLGCAWKNLSASGASADVAYQSTVVNIPYKILKSGLRKFQRSKETNTFQILKPMD
GCLNPGELLVVLGRPGSGCTTLLKSISSNTHGFDLGADTKISYSGYSGDDIKKHFRGEVV
YNAEADVHLPHLTVFETLVTVARLKTPQNRIKGVDRESYANHLAEVAMATYGLSHTRNTK
VGNDIVRGVSGGERKRVSIAEVSICGSKFQCWDNATRGLDSATALEFIRALKTQADISNT
SATVAIYQCSQDAYDLFNKVCVLDDGYQIYYGPADKAKKYFEDMGYVCPSRQTTADFLTS
VTSPSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVDQRLLNDDEASREAIK
EAHIAKQSKRARPSSPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMALILGSM
FFKIMKKGDTSTFYFRGSAMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADA
FASVLSEIPSKLIIAVCFNIIFYFLVDFRRNGGVFFFYLLINIVAVFSMSHLFRCVGSLT
KTLSEAMVPASMLLLALSMYTGFAIPKKKILRWSKWIWYINPLAYLFESLLINEFHGIKF
PCAEYVPRGPAYANISSTESVCTVVGAVPGQDYVLGDDFIRGTYQYYHKDKWRGFGIGMA
YVVFFFFVYLFLCEYNEGAKQKGEILVFPRSIVKRMKKRGVLTEKNANDPENVGERSDLS
SDRKMLQESSEEESDTYGEIGLSKSEAIFHWRNLCYEVQIKAETRRILNNVDGWVKPGTL
TALMGASGAGKTTLLDCLAERVTMGVITGDILVNGIPRDKSFPRSIGYCQQQDLHLKTAT
VRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEMEKYADAVVGVAGEGLNVEQRKRLTI
GVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDR
LLFMQRGGKTVYFGDLGEGCKTMIDYFESHGAHKCPADANPAEWMLEVVGAAPGSHANQD
YYEVWRNSEEYRAVQSELDWMERELPKKGSITAAEDKHEFSQSIIYQTKLVSIRLFQQYW
RSPDYLWSKFILTIFNQLFIGFTFFKAGTSLQGLQNQMLAVFMFTVIFNPILQQYLPSFV
QQRDLYEARERPSRTFSWISFIFAQIFVEVPWNILAGTIAYFIYYYPIGFYSNASAAGQL
HERGALFWLFSCAFYVYVGSMGLLVISFNQVAESAANLASLLFTMSLSFCGVMTTPSAMP
RFWIFMYRVSPLTYFIQALLAVGVANVDVKCADYELLEFTPPSGMTCGQYMEPYLQLAKT
GYLTDENATDTCSFCQISTTNDYLANVNSFYSERWRNYGIFICYIAFNYIAGVFFYWLAR
VPKKNGKLSKK
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| BDBM50339134 |
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| n/a |
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| Name | BDBM50339134 |
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| Synonyms: | 3-(2-Chloro-phenothiazin-10-yl)-propylamine | 3-(2-chloro-10H-phenothiazin-10-yl)propan-1-amine | CHEMBL824 | Nor2-Chlorpromazine |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN2S |
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| Mol. Mass. | 290.811 |
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| SMILES | NCCCN1c2ccccc2Sc2ccc(Cl)cc12 |
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| Structure | 
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