| Reaction Details |
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 | Report a problem with these data |
| Target | Orotidine 5'-phosphate decarboxylase |
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| Ligand | BDBM50341908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_743288 (CHEMBL1767487) |
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| Ki | 630±n/a nM |
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| Citation |  Lewis, M; Meza-Avina, ME; Wei, L; Crandall, IE; Bello, AM; Poduch, E; Liu, Y; Paige, CJ; Kain, KC; Pai, EF; Kotra, LP Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem54:2891-901 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orotidine 5'-phosphate decarboxylase |
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| Name: | Orotidine 5'-phosphate decarboxylase |
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| Synonyms: | OMP decarboxylase | OMPDCase | Orotidine 5-phosphate decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase) | PYRF_METTH | pyrF |
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| Type: | Enzyme |
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| Mol. Mass.: | 24909.45 |
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| Organism: | Methanobacterium thermoautotrophicum |
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| Description: | n/a |
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| Residue: | 228 |
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| Sequence: | MRSRRVDVMDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR
KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFRGADSVRACLNVAEEMGREV
FLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTRPERLSRLREIIGQDSFLISP
GVGAQGGDPGETLRFADAIIVGRSIYLADNPAAAAAGIIESIKDLLNP
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| BDBM50341908 |
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| n/a |
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| Name | BDBM50341908 |
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| Synonyms: | ((2S,3S,4R,5R)-5-(5-azido-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphonate | CHEMBL1765125 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H12N5O8P |
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| Mol. Mass. | 349.194 |
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| SMILES | O[C@@H]1[C@@H](CP(O)(O)=O)O[C@H]([C@@H]1O)n1cc(N=[N+]=[N-])c(=O)[nH]c1=O |r| |
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| Structure | 
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