Reaction Details |
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Target | Uridine 5'-monophosphate synthase |
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Ligand | BDBM50341905 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_743290 (CHEMBL1767489) |
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Ki | >2000000±n/a nM |
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Citation | Lewis, M; Meza-Avina, ME; Wei, L; Crandall, IE; Bello, AM; Poduch, E; Liu, Y; Paige, CJ; Kain, KC; Pai, EF; Kotra, LP Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase. J Med Chem54:2891-901 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Uridine 5'-monophosphate synthase |
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Name: | Uridine 5'-monophosphate synthase |
Synonyms: | Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 52224.99 |
Organism: | Homo sapiens (Human) |
Description: | P11172 |
Residue: | 480 |
Sequence: | MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
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BDBM50341905 |
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n/a |
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Name | BDBM50341905 |
Synonyms: | CHEMBL1765124 | ammonium 6-Cyano-2'-deoxy-2'-fluoro-beta-D-uridine 5'-O-Monophosphate |
Type | Small organic molecule |
Emp. Form. | C10H9FN3O7P |
Mol. Mass. | 333.1676 |
SMILES | O[C@@H]1[C@@H](CP([O-])([O-])=O)O[C@H]([C@@H]1F)n1c(cc(=O)[nH]c1=O)C#N |r| |
Structure |
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