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TargetTranslocator protein
LigandBDBM50342052
Substrate/Competitorn/a
Meas. Tech.ChEMBL_743741 (CHEMBL1767555)
Ki 880±n/a nM
Citation Donohue, SRDannals, RFHalldin, CPike, VW N-(4-cyanotetrahydro-2H-pyran-4-yl) and N-(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors. J Med Chem54:2961-70 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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  Blast E-value cutoff:
BDBM50342052
n/a
NameBDBM50342052
Synonyms:1-(2-Chlorophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-N,4-dimethyl-5-phenyl-1H-pyrazole-3-carboxamide | CHEMBL1765096
TypeSmall organic molecule
Emp. Form.C24H23ClN4O2
Mol. Mass.434.918
SMILESCN(C(=O)c1nn(c(c1C)-c1ccccc1)-c1ccccc1Cl)C1(CCOCC1)C#N
Structure
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