| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 22 member 6 |
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| Ligand | BDBM50027886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_749030 (CHEMBL1781815) |
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| Ki | 55500±n/a nM |
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| Citation |  Kouznetsova, VL; Tsigelny, IF; Nagle, MA; Nigam, SK Elucidation of common pharmacophores from analysis of targeted metabolites transported by the multispecific drug transporter-Organic anion transporter1 (Oat1). Bioorg Med Chem19:3320-40 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 22 member 6 |
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| Name: | Solute carrier family 22 member 6 |
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| Synonyms: | Oat1 | Organic anion transporter 1 | S22A6_RAT | Slc22a6 | rOAT1 | rROAT1 | renal organic anion transporter 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60784.17 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_838479 |
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| Residue: | 551 |
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| Sequence: | MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKD
GGLEAWLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTI
VTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
YAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGI
AYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEE
GAKLSIEVLRTSLQKELTLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHT
IIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAE
FYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQQEQQKQMMP
LQASTQEKNGL
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| BDBM50027886 |
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| n/a |
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| Name | BDBM50027886 |
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| Synonyms: | 1-Butyl-3-(p-methylphenylsulfonyl)urea | 1-Butyl-3-(p-tolylsulfonyl)urea | 1-Butyl-3-tosylurea | CHEMBL782 | N-(4-Methylphenylsulfonyl)-N'-butylurea | N-Butyl-N'-(4-methylphenylsulfonyl)urea | N-Butyl-N'-(p-tolylsulfonyl)urea | N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide | N-n-Butyl-N'-tosylurea | Orinase (TN) | TOLBUTAMIDE |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N2O3S |
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| Mol. Mass. | 270.348 |
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| SMILES | CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 |
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| Structure | 
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