| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50345690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_750511 (CHEMBL1786272) |
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| IC50 | 65±n/a nM |
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| Citation |  Lainé, DI; Wan, Z; Yan, H; Zhu, C; Xie, H; Fu, W; Busch-Petersen, J; Neipp, C; Davis, R; Widdowson, KL; Blaney, FE; Foley, J; Bacon, AM; Webb, EF; Luttmann, MA; Burman, M; Sarau, HM; Salmon, M; Palovich, MR; Belmonte, K Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists. J Med Chem52:5241-52 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 66151.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20309 |
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| Residue: | 590 |
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| Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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| BDBM50345690 |
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| n/a |
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| Name | BDBM50345690 |
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| Synonyms: | (3-endo)-3-[2-Hydroxy-2,2-bis(4-methyl-3-thienyl)ethyl]-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane Bromide | CHEMBL1785080 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30NOS2 |
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| Mol. Mass. | 376.598 |
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| SMILES | Cc1cc(cs1)C(O)(CC1C[C@H]2CC[C@H](C1)[N+]2(C)C)c1csc(C)c1 |r,TLB:8:9:16:12.13| |
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| Structure | 
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