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TargetCalmodulin-domain protein kinase 1
LigandBDBM50298225
Substrate/Competitorn/a
Meas. Tech.ChEMBL_750529 (CHEMBL1786290)
IC50 31±n/a nM
Citation Murphy, RC; Ojo, KK; Larson, ET; Castellanos-Gonzalez, A; Perera, BG; Keyloun, KR; Kim, JE; Bhandari, JG; Muller, NR; Verlinde, CL; White, AC; Merritt, EA; Van Voorhis, WC; Maly, DJ Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett1:331-335 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calmodulin-domain protein kinase 1
Name:Calmodulin-domain protein kinase 1
Synonyms:Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative
Type:Enzyme Catalytic Domain
Mol. Mass.:57248.42
Organism:Toxoplasma gondii
Description:n/a
Residue:507
Sequence:
MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50298225
n/a
NameBDBM50298225
Synonyms:CHEMBL2069955 | CHEMBL573578 | NM-PP1 | US10544104, Compound 5d | US11247972, Compound 5d | US9765037, Compound 5d
TypeSmall organic molecule
Emp. Form.C20H21N5
Mol. Mass.331.4142
SMILESCC(C)(C)n1nc(Cc2cccc3ccccc23)c2c(N)ncnc12
Structure
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