| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50347659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_756009 (CHEMBL1803985) |
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| IC50 | >100000±n/a nM |
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| Citation |  Katz, JD; Jewell, JP; Guerin, DJ; Lim, J; Dinsmore, CJ; Deshmukh, SV; Pan, BS; Marshall, CG; Lu, W; Altman, MD; Dahlberg, WK; Davis, L; Falcone, D; Gabarda, AE; Hang, G; Hatch, H; Holmes, R; Kunii, K; Lumb, KJ; Lutterbach, B; Mathvink, R; Nazef, N; Patel, SB; Qu, X; Reilly, JF; Rickert, KW; Rosenstein, C; Soisson, SM; Spencer, KB; Szewczak, AA; Walker, D; Wang, W; Young, J; Zeng, Q Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem54:4092-108 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50347659 |
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| n/a |
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| Name | BDBM50347659 |
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| Synonyms: | CHEMBL1802916 | MK-2461 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N5O5S |
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| Mol. Mass. | 495.551 |
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| SMILES | CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r| |
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| Structure | 
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