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TargetCytochrome P450 2D6
LigandBDBM50347656
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756009 (CHEMBL1803985)
IC50>50000±n/a nM
Citation Katz, JDJewell, JPGuerin, DJLim, JDinsmore, CJDeshmukh, SVPan, BSMarshall, CGLu, WAltman, MDDahlberg, WKDavis, LFalcone, DGabarda, AEHang, GHatch, HHolmes, RKunii, KLumb, KJLutterbach, BMathvink, RNazef, NPatel, SBQu, XReilly, JFRickert, KWRosenstein, CSoisson, SMSpencer, KBSzewczak, AAWalker, DWang, WYoung, JZeng, Q Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer. J Med Chem54:4092-108 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6
Name:Cytochrome P450 2D6
Synonyms:CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50347656
n/a
NameBDBM50347656
Synonyms:CHEMBL1803004
TypeSmall organic molecule
Emp. Form.C21H16N2O3S
Mol. Mass.376.428
SMILESCS(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1ccccc1
Structure
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