Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase 14 | ||
| Ligand | BDBM50347930 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_756761 (CHEMBL1805307) | ||
| IC50 | 9.5±n/a nM | ||
| Citation |  Selness, SR; Devraj, RV; Devadas, B; Walker, JK; Boehm, TL; Durley, RC; Shieh, H; Xing, L; Rucker, PV; Jerome, KD; Benson, AG; Marrufo, LD; Madsen, HM; Hitchcock, J; Owen, TJ; Christie, L; Promo, MA; Hickory, BS; Alvira, E; Naing, W; Blevis-Bal, R; Messing, D; Yang, J; Mao, MK; Yalamanchili, G; Vonder Embse, R; Hirsch, J; Saabye, M; Bonar, S; Webb, E; Anderson, G; Monahan, JB Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett21:4066-71 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase 14 | |||
| Name: | Mitogen-activated protein kinase 14 | ||
| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 41286.76 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16539 | ||
| Residue: | 360 | ||
| Sequence: |
| ||
| BDBM50347930 | |||
| n/a | |||
| Name | BDBM50347930 | ||
| Synonyms: | CHEMBL1802633 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H21BrF2N2O3 | ||
| Mol. Mass. | 491.325 | ||
| SMILES | CN(C)C(=O)c1ccc(C)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(19.71,-15.18,;19.71,-13.64,;21.04,-12.87,;18.37,-12.87,;17.04,-13.64,;18.37,-11.33,;19.71,-10.56,;19.7,-9.01,;18.36,-8.25,;18.36,-6.71,;17.05,-9.02,;17.04,-10.56,;15.71,-8.26,;15.7,-6.71,;17.04,-5.93,;14.37,-5.94,;13.04,-6.71,;11.71,-5.94,;10.37,-6.71,;9.04,-5.94,;7.72,-6.71,;6.38,-5.95,;6.38,-4.4,;5.04,-3.63,;7.71,-3.63,;9.05,-4.4,;10.38,-3.63,;13.04,-8.26,;11.7,-9.03,;14.37,-9.03,;14.37,-10.57,)| | ||
| Structure | 
| ||