Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMitogen-activated protein kinase 14
LigandBDBM50347933
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756761
IC50 8.5±n/a nM
Citation Selness SRDevraj RVDevadas BWalker JKBoehm TLDurley RCShieh HXing LRucker PVJerome KDBenson AGMarrufo LDMadsen HMHitchcock JOwen TJChristie LPromo MAHickory BSAlvira ENaing WBlevis-Bal RMessing DYang JMao MKYalamanchili GVonder Embse RHirsch JSaabye MBonar SWebb EAnderson GMonahan JB Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett 21:4066-71 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | Cytokine suppressive anti-inflammatory drug-binding protein | MAP Kinase p38 alpha | MAP kinase MXI2 | MAP kinase p38 | MAX-interacting protein 2 | Mitogen-activated protein kinase (MAP) p38 alpha | Mitogen-activated protein kinase (Map p38 alpha) | Mitogen-activated protein kinase 14 (MAP kinase p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14 p38 alpha) | Mitogen-activated protein kinase 14 (MAPK14) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKa) | Mitogen-activated protein kinase 14 (MAPK14) (p38 MAPKÿ±) | Mitogen-activated protein kinase 14 (p38 MAPKa) | Mitogen-activated protein kinase 14 (p38 alpha) | Mitogen-activated protein kinase 14, activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 alpha (p38 MAPKa) | SAPK2A | p38-alpha
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50347933
n/a
NameBDBM50347933
Synonyms:CHEMBL1802636
TypeSmall organic molecule
Emp. Form.C21H16BrF3N2O3
Mol. Mass.481.263
SMILESCNC(=O)c1ccc(F)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(21.06,-26.62,;21.02,-25.08,;22.34,-24.28,;23.69,-25.02,;22.31,-22.75,;23.64,-21.98,;23.63,-20.43,;22.3,-19.67,;22.29,-18.13,;20.98,-20.44,;20.97,-21.98,;19.65,-19.67,;19.64,-18.12,;20.97,-17.35,;18.31,-17.36,;16.98,-18.13,;15.64,-17.36,;14.31,-18.13,;12.98,-17.36,;11.65,-18.13,;10.32,-17.37,;10.31,-15.82,;8.98,-15.05,;11.65,-15.05,;12.98,-15.82,;14.32,-15.05,;16.97,-19.67,;15.64,-20.44,;18.31,-20.45,;18.31,-21.99,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: