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TargetMitogen-activated protein kinase 14
LigandBDBM50347935
Substrate/Competitorn/a
Meas. Tech.ChEMBL_756761 (CHEMBL1805307)
IC50>10000±n/a nM
Citation Selness, SRDevraj, RVDevadas, BWalker, JKBoehm, TLDurley, RCShieh, HXing, LRucker, PVJerome, KDBenson, AGMarrufo, LDMadsen, HMHitchcock, JOwen, TJChristie, LPromo, MAHickory, BSAlvira, ENaing, WBlevis-Bal, RMessing, DYang, JMao, MKYalamanchili, GVonder Embse, RHirsch, JSaabye, MBonar, SWebb, EAnderson, GMonahan, JB Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg Med Chem Lett21:4066-71 (2011) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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  Blast E-value cutoff:
BDBM50347935
n/a
NameBDBM50347935
Synonyms:CHEMBL1802639
TypeSmall organic molecule
Emp. Form.C22H17BrF2N2O5
Mol. Mass.507.282
SMILESCNC(=O)c1ccc(C(O)=O)c(c1)-n1c(C)cc(OCc2ccc(F)cc2F)c(Br)c1=O |(20.52,-39.27,;20.49,-37.73,;21.8,-36.93,;23.15,-37.67,;21.77,-35.4,;23.1,-34.62,;23.1,-33.08,;21.76,-32.32,;21.75,-30.77,;23.08,-29.99,;20.41,-30.01,;20.44,-33.09,;20.44,-34.63,;19.11,-32.32,;19.1,-30.77,;19.09,-29.23,;17.77,-30.01,;16.44,-30.78,;15.11,-30.01,;13.77,-30.78,;12.44,-30.01,;11.12,-30.78,;9.78,-30.02,;9.78,-28.47,;8.44,-27.7,;11.11,-27.7,;12.44,-28.47,;13.78,-27.7,;16.44,-32.32,;15.1,-33.09,;17.77,-33.09,;17.77,-34.63,)|
Structure
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