Reaction Details |
| Report a problem with these data |
Target | Dihydrofolate reductase |
---|
Ligand | BDBM50348434 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_755432 (CHEMBL1804901) |
---|
IC50 | 8.4±n/a nM |
---|
Citation | Ma, X; Chui, WK Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes. Bioorg Med Chem18:737-43 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Dihydrofolate reductase |
---|
Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
Type: | Enzyme |
Mol. Mass.: | 21603.71 |
Organism: | Bos taurus (Cattle) |
Description: | P00376 |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
|
|
|
BDBM50348434 |
---|
n/a |
---|
Name | BDBM50348434 |
Synonyms: | CHEMBL1800940 |
Type | Small organic molecule |
Emp. Form. | C16H22N6O4 |
Mol. Mass. | 362.3837 |
SMILES | NC1=NC2(CCCC2)N(OCCCOc2ccc(cc2)[N+]([O-])=O)C(N)=N1 |c:26,t:1| |
Structure |
|