Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50348442 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_755432 (CHEMBL1804901) |
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IC50 | 13.8±n/a nM |
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Citation | Ma, X; Chui, WK Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes. Bioorg Med Chem18:737-43 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
Type: | Enzyme |
Mol. Mass.: | 21603.71 |
Organism: | Bos taurus (Cattle) |
Description: | P00376 |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM50348442 |
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n/a |
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Name | BDBM50348442 |
Synonyms: | CHEMBL1800948 |
Type | Small organic molecule |
Emp. Form. | C17H24ClN5O2 |
Mol. Mass. | 365.858 |
SMILES | NC1=NC2(CCCCC2)N(OCCCOc2ccc(Cl)cc2)C(N)=N1 |c:25,t:1| |
Structure |
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