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TargetDihydrofolate reductase
LigandBDBM50348444
Substrate/Competitorn/a
Meas. Tech.ChEMBL_755432 (CHEMBL1804901)
IC50 17.5±n/a nM
Citation Ma, XChui, WK Antifolate and antiproliferative activity of 6,8,10-triazaspiro[4.5]deca-6,8-dienes and 1,3,5-triazaspiro[5.5]undeca-1,3-dienes. Bioorg Med Chem18:737-43 (2010) [PubMed]  Article
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:Enzyme
Mol. Mass.:21603.71
Organism:Bos taurus (Cattle)
Description:P00376
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM50348444
n/a
NameBDBM50348444
Synonyms:CHEMBL1801198
TypeSmall organic molecule
Emp. Form.C18H27N5O2
Mol. Mass.345.4393
SMILESCc1ccc(OCCCON2C(N)=NC(N)=NC22CCCCC2)cc1 |c:12,15|
Structure
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