Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM50350021 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_768593 (CHEMBL1832612) |
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Ki | 7.2±n/a nM |
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Citation | Hudkins, RL; Aimone, LD; Bailey, TR; Bendesky, RJ; Dandu, RR; Dunn, D; Gruner, JA; Josef, KA; Lin, YG; Lyons, J; Marcy, VR; Mathiasen, JR; Sundar, BG; Tao, M; Zulli, AL; Raddatz, R; Bacon, ER Identification of pyridazin-3-one derivatives as potent, selective histamine H3 receptor inverse agonists with robust wake activity. Bioorg Med Chem Lett21:5493-7 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | HH3R | HRH3_RAT | Hrh3 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48607.98 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 445 |
Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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BDBM50350021 |
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n/a |
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Name | BDBM50350021 |
Synonyms: | CHEMBL1813067 |
Type | Small organic molecule |
Emp. Form. | C18H23N3O2 |
Mol. Mass. | 313.3941 |
SMILES | C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1 |r| |
Structure |
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