| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50379308 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_811974 (CHEMBL2013344) |
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| IC50 | 8±n/a nM |
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| Citation |  Mihalic, JT; Kim, YJ; Lizarzaburu, M; Chen, X; Deignan, J; Wanska, M; Yu, M; Fu, J; Chen, X; Zhang, A; Connors, R; Liang, L; Lindstrom, M; Ma, J; Tang, L; Dai, K; Li, L Discovery of a new class of ghrelin receptor antagonists. Bioorg Med Chem Lett22:2046-51 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50379308 |
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| n/a |
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| Name | BDBM50379308 |
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| Synonyms: | CHEMBL2011816 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H36N4O4 |
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| Mol. Mass. | 540.6526 |
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| SMILES | CC(C)[C@@H](N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O)C(=O)NC1CCN(Cc2ccccc2)CC1 |r| |
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| Structure | 
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