Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 1

Ligand

BDBM50379506

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_812218 (CHEMBL2013813)

IC50

38±n/a nM

Citation

Le Brazidec, JY; Pasis, A; Tam, B; Boykin, C; Black, C; Wang, D; Claassen, G; Chong, JH; Chao, J; Fan, J; Nguyen, K; Silvian, L; Ling, L; Zhang, L; Choi, M; Teng, M; Pathan, N; Zhao, S; Li, T; Taveras, A Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1. Bioorg Med Chem Lett22:2070-4 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 1

Name:

Cyclin-dependent kinase 1

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

34101.08

Organism:

Homo sapiens (Human)

Description:

P06493

Residue:

297

Sequence:

MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM

BDBM50379506

n/a

Name

BDBM50379506

Synonyms:

CHEMBL2012397

Type

Small organic molecule

Emp. Form.

C21H25N7O

Mol. Mass.

391.4695

SMILES

Cn1cc(Nc2ncc3cnn(C4C5CC6CC(C5)CC4C6)c3n2)cc1C(N)=O |THB:19:17:14:12.21.20,16:17:12:14.15.21,(-6.38,-15.11,;-7.29,-13.87,;-6.81,-12.4,;-8.06,-11.49,;-8.06,-9.95,;-6.73,-9.18,;-6.72,-7.63,;-5.39,-6.86,;-4.06,-7.63,;-2.59,-7.14,;-1.67,-8.38,;-2.58,-9.64,;-2.58,-11.18,;-3.92,-11.94,;-3.92,-13.48,;-2.58,-14.26,;-3.29,-13.44,;-2.59,-12.34,;-3.35,-12.69,;-2.07,-12.75,;-1.24,-11.94,;-1.25,-13.49,;-4.05,-9.17,;-5.39,-9.95,;-9.3,-12.39,;-8.83,-13.87,;-9.88,-15,;-11.39,-14.66,;-9.41,-16.47,)|

Structure