| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM50379508 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_812218 (CHEMBL2013813) |
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| IC50 | 19±n/a nM |
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| Citation |  Le Brazidec, JY; Pasis, A; Tam, B; Boykin, C; Black, C; Wang, D; Claassen, G; Chong, JH; Chao, J; Fan, J; Nguyen, K; Silvian, L; Ling, L; Zhang, L; Choi, M; Teng, M; Pathan, N; Zhao, S; Li, T; Taveras, A Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1. Bioorg Med Chem Lett22:2070-4 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM50379508 |
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| n/a |
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| Name | BDBM50379508 |
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| Synonyms: | CHEMBL2012400 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23N7O |
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| Mol. Mass. | 365.4322 |
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| SMILES | Cn1cc(Nc2ncc3cnn(C4CCC5(CC5)CC4)c3n2)cc1C(N)=O |
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| Structure | 
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