Ki Summary

Reaction Details

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Target

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Ligand

BDBM100152

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_810201 (CHEMBL2015537)

IC50

690±n/a nM

Citation

Cuny, GD; Ulyanova, NP; Patnaik, D; Liu, JF; Lin, X; Auerbach, K; Ray, SS; Xian, J; Glicksman, MA; Stein, RL; Higgins, JM Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett22:2015-9 (2012) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Name:

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Synonyms:

DYRK2 | DYRK2_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 2

Type:

PROTEIN

Mol. Mass.:

66690.69

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1508025

Residue:

601

Sequence:

MLTRKPSAAAPAAYPTGRGGDSAVRQLQASPGLGAGATRSGVGTGPPSPIALPPLRASNA
AAAAHTIGGSKHTMNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLP
VVPERQLDSIHRRQGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPE
IYFLGLNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAY
DHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMT
FELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG
RSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYP
LLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGG
RSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLP
KPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLV
S

BDBM100152

n/a

Name

BDBM100152

Synonyms:

7-methoxy-1-methyl-9H-beta-carboline;hydrochloride | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride | HARMINE | Harmine hydrochloride | MLS002153910 | SMR001233259 | cid_5359389

Type

Small organic molecule

Emp. Form.

C13H12N2O

Mol. Mass.

212.2472

SMILES

COc1ccc2c(c1)[nH]c1c(C)nccc21

Structure