Reaction Details |
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Target | Cannabinoid receptor 2 |
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Ligand | BDBM50379695 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_812056 (CHEMBL2013482) |
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IC50 | 1.95±n/a nM |
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Citation | Nelson, DW; Frost, JM; Tietje, KR; Florjancic, AS; Ryther, K; Carroll, WA; Dart, MJ; Daza, AV; Hooker, BA; Grayson, GK; Fan, Y; Garrison, TR; El-Kouhen, OF; Yao, B; Pai, M; Chandran, P; Zhu, C; Hsieh, GC; Meyer, MD Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB2 receptor agonists for pain management. Bioorg Med Chem Lett22:2604-8 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cannabinoid receptor 2 |
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Name: | Cannabinoid receptor 2 |
Synonyms: | CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 39690.94 |
Organism: | Homo sapiens (Human) |
Description: | P34972 |
Residue: | 360 |
Sequence: | MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
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BDBM50379695 |
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n/a |
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Name | BDBM50379695 |
Synonyms: | CHEMBL2010898 |
Type | Small organic molecule |
Emp. Form. | C21H28N2O3S |
Mol. Mass. | 388.524 |
SMILES | CCCNC(=O)c1c(NC(=O)C23CC4CC2CC(C3)C4)sc2COCCc12 |TLB:12:11:19.13.14:16,THB:9:11:19.13.14:16,12:13:16:18.11| |
Structure |
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