Reaction Details |
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Target | P2X purinoceptor 3 |
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Ligand | BDBM50379716 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_812331 (CHEMBL2014010) |
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IC50 | 24±n/a nM |
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Citation | Cantin, LD; Bayrakdarian, M; Buon, C; Grazzini, E; Hu, YJ; Labrecque, J; Leung, C; Luo, X; Martino, G; Paré, M; Payza, K; Popovic, N; Projean, D; Santhakumar, V; Walpole, C; Yu, XH; Tomaszewski, MJ Discovery of P2X3 selective antagonists for the treatment of chronic pain. Bioorg Med Chem Lett22:2565-71 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 3 |
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Name: | P2X purinoceptor 3 |
Synonyms: | ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa |
Type: | Protein |
Mol. Mass.: | 44292.02 |
Organism: | Homo sapiens (Human) |
Description: | P56373 |
Residue: | 397 |
Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS
QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE
VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
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BDBM50379716 |
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n/a |
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Name | BDBM50379716 |
Synonyms: | CHEMBL2011125 |
Type | Small organic molecule |
Emp. Form. | C25H29N7O2 |
Mol. Mass. | 459.5435 |
SMILES | CC(C)N1Cc2c(nc(nc2NCc2cnc3ccccc3c2)N2CCN(CC2)C(C)=O)C1=O |
Structure |
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