| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
|---|
| Ligand | BDBM50379757 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_812462 (CHEMBL2014248) |
|---|
| IC50 | 29±n/a nM |
|---|
| Citation |  Dudkin, VY; Rickert, K; Kreatsoulas, C; Wang, C; Arrington, KL; Fraley, ME; Hartman, GD; Yan, Y; Ikuta, M; Stirdivant, SM; Drakas, RA; Walsh, ES; Hamilton, K; Buser, CA; Lobell, RB; Sepp-Lorenzino, L Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates. Bioorg Med Chem Lett22:2609-12 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 |
|---|
| Name: | Serine/threonine-protein kinase Chk1 |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54443.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_166295192 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
|---|
| BDBM50379757 |
|---|
| n/a |
|---|
| Name | BDBM50379757 |
|---|
| Synonyms: | CHEMBL2011340 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H19N7S |
|---|
| Mol. Mass. | 341.434 |
|---|
| SMILES | Cc1ncc(cn1)-c1cnc(Nc2cccc(NCCCN)n2)s1 |
|---|
| Structure | 
|
|---|
Search and Browse
