| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-beta |
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| Ligand | BDBM19993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_810759 (CHEMBL2015992) |
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| IC50 | 100±n/a nM |
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| Citation |  Kopecky, DJ; Jiao, XY; Fisher, B; McKendry, S; Labelle, M; Piper, DE; Coward, P; Shiau, AK; Escaron, P; Danao, J; Chai, A; Jaen, J; Kayser, F Discovery of a new binding mode for a series of liver X receptor agonists. Bioorg Med Chem Lett22:2407-10 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-beta |
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| Name: | Oxysterols receptor LXR-beta |
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| Synonyms: | LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50978.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55055 |
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| Residue: | 460 |
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| Sequence: | MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM19993 |
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| n/a |
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| Name | BDBM19993 |
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| Synonyms: | CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide | T 0901317 | T0901317 | TO-901317 | US10543183, Compound TO901317 | US10669296, Compound TO901317 | US10945978, Compound 1 | [3H]T0901317 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12F9NO3S |
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| Mol. Mass. | 481.333 |
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| SMILES | OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F |
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| Structure | 
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