| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50380140 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_811724 (CHEMBL2014299) |
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| Kd | 430±n/a nM |
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| Citation |  Capkauskaite, E; Zubriene, A; Baranauskiene, L; Tamulaitiene, G; Manakova, E; Kairys, V; Gražulis, S; Tumkevicius, S; Matulis, D Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases. Eur J Med Chem51:259-70 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50380140 |
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| n/a |
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| Name | BDBM50380140 |
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| Synonyms: | CHEMBL2011155 | carbonic anhydrase (CA) inhibitors, benzenesulphonamide ligand, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10ClN3O3S2 |
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| Mol. Mass. | 343.809 |
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| SMILES | NS(=O)(=O)c1cc(ccc1Cl)C(=O)CSc1ncccn1 |
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| Structure | 
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