| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Ligand | BDBM50380246 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_813552 (CHEMBL2019661) |
|---|
| IC50 | >40000±n/a nM |
|---|
| Citation |  Maryanoff, BE; McComsey, DF; Yabut, SC; Luci, DK; Jordan, AD; Masucci, JA; Jones, WJ; Abad, MC; Gibbs, AC; Petrounia, I Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett2:538-543 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Name: | 5'-AMP-activated protein kinase subunit gamma-1 |
|---|
| Synonyms: | 5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1 |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 37581.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54619 |
|---|
| Residue: | 331 |
|---|
| Sequence: | METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKA
FFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREV
YLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFI
TEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDI
YSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRL
VVVDENDVVKGIVSLSDILQALVLTGGEKKP
|
|
|
|---|
| BDBM50380246 |
|---|
| n/a |
|---|
| Name | BDBM50380246 |
|---|
| Synonyms: | CHEMBL2017214 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H26N8S |
|---|
| Mol. Mass. | 422.55 |
|---|
| SMILES | CSc1ccccc1Nc1nc(nc2c(NCC3CC3)ncnc12)N1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
