Reaction Details |
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Target | Renin |
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Ligand | BDBM50380981 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_814099 (CHEMBL2020693) |
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IC50 | 0.26±n/a nM |
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Citation | Fournier, PA; Arbour, M; Cauchon, E; Chen, A; Chefson, A; Ducharme, Y; Falgueyret, JP; Gagné, S; Grimm, E; Han, Y; Houle, R; Lacombe, P; Lévesque, JF; MacDonald, D; Mackay, B; McKay, D; Percival, MD; Ramtohul, Y; St-Jacques, R; Toulmond, S Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorg Med Chem Lett22:2670-4 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Renin |
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Name: | Renin |
Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 45058.99 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 406 |
Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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BDBM50380981 |
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n/a |
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Name | BDBM50380981 |
Synonyms: | CHEMBL2017109 |
Type | Small organic molecule |
Emp. Form. | C24H24BrF2N3O2 |
Mol. Mass. | 504.367 |
SMILES | CC(=O)NCCc1ccccc1-c1onc([C@H]2CNCC[C@@H]2c2ccc(F)c(F)c2)c1Br |r| |
Structure |
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