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TargetRenin
LigandBDBM50380988
Substrate/Competitorn/a
Meas. Tech.ChEMBL_814099
IC50 0.47±n/a nM
Citation Fournier PAArbour MCauchon EChen AChefson ADucharme YFalgueyret JPGagné SGrimm EHan YHoule RLacombe PLévesque JFMacDonald DMackay BMcKay DPercival MDRamtohul YSt-Jacques RToulmond S Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorg Med Chem Lett 22:2670-4 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Renin
Name:Renin
Synonyms:Angiotensinogenase
Type:Enzyme
Mol. Mass.:45058.99
Organism:Homo sapiens (Human)
Description:n/a
Residue:406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50380988
n/a
NameBDBM50380988
Synonyms:CHEMBL2017098
TypeSmall organic molecule
Emp. Form.C22H21BrF2N2O2
Mol. Mass.463.315
SMILESCc1cccc(-c2noc([C@H]3CNCC[C@]3(O)c3ccc(F)c(F)c3)c2Br)c1C |r|
Structure
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