Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase PknB |
---|
Ligand | BDBM50381106 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_814187 (CHEMBL2020901) |
---|
IC50 | 176±n/a nM |
---|
Citation | Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KE; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL; Whalley, D Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett22:3349-53 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Serine/threonine-protein kinase PknB |
---|
Name: | Serine/threonine-protein kinase PknB |
Synonyms: | PKNB_MYCTU | pknB |
Type: | PROTEIN |
Mol. Mass.: | 66497.93 |
Organism: | Mycobacterium tuberculosis |
Description: | ChEMBL_774233 |
Residue: | 626 |
Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
|
|
|
BDBM50381106 |
---|
n/a |
---|
Name | BDBM50381106 |
Synonyms: | CHEMBL2017870 |
Type | Small organic molecule |
Emp. Form. | C21H23ClN6 |
Mol. Mass. | 394.901 |
SMILES | CN(C)[C@@H]1CCN(C1)c1cc(Nc2cc(Cl)ccn2)nc(n1)-c1ccccc1 |r| |
Structure |
|