| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PknB |
|---|
| Ligand | BDBM50381130 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_814187 (CHEMBL2020901) |
|---|
| IC50 | 73±n/a nM |
|---|
| Citation |  Chapman, TM; Bouloc, N; Buxton, RS; Chugh, J; Lougheed, KE; Osborne, SA; Saxty, B; Smerdon, SJ; Taylor, DL; Whalley, D Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett22:3349-53 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PknB |
|---|
| Name: | Serine/threonine-protein kinase PknB |
|---|
| Synonyms: | PKNB_MYCTU | pknB |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 66497.93 |
|---|
| Organism: | Mycobacterium tuberculosis |
|---|
| Description: | ChEMBL_774233 |
|---|
| Residue: | 626 |
|---|
| Sequence: | MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
|
|
|
|---|
| BDBM50381130 |
|---|
| n/a |
|---|
| Name | BDBM50381130 |
|---|
| Synonyms: | CHEMBL2017731 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N7 |
|---|
| Mol. Mass. | 389.4967 |
|---|
| SMILES | CN1CCC(CC1)Nc1cc(Nc2cc(n[nH]2)C2CC2)nc(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
