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TargetSerine/threonine-protein kinase pknB
LigandBDBM50381138
Substrate/Competitorn/a
Meas. Tech.ChEMBL_814187
IC50 1130±n/a nM
Citation Chapman TMBouloc NBuxton RSChugh JLougheed KEOsborne SASaxty BSmerdon SJTaylor DLWhalley D Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett 22:3349-53 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pknB
Name:Serine/threonine-protein kinase pknB
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:66497.93
Organism:Mycobacterium tuberculosis
Description:ChEMBL_774233
Residue:626
Sequence:
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFYLRFRREA
QNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIA
DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA
QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSARH
EGLSADLDAVVLKALAKNPENRYQTAAEMRADLVRVHNGEPPEAPKVLTDAERTSLLSSA
AGNLSGPRTDPLPRQDLDDTDRDRSIGSVGRWVAVVAVLAVLTVVVTIAINTFGGITRDV
QVPDVRGQSSADAIATLQNRGFKIRTLQKPDSTIPPDHVIGTDPAANTSVSAGDEITVNV
STGPEQREIPDVSTLTYAEAVKKLTAAGFGRFKQANSPSTPELVGKVIGTNPPANQTSAI
TNVVIIIVGSGPATKDIPDVAGQTVDVAQKNLNVYGFTKFSQASVDSPRPAGEVTGTNPP
AGTTVPVDSVIELQVSKGNQFVMPDLSGMFWVDAEPRLRALGWTGMLDKGADVDAGGSQH
NRVVYQNPPAGTGVNRDGIITLRFGQ
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  Blast E-value cutoff:
BDBM50381138
n/a
NameBDBM50381138
Synonyms:CHEMBL2017739
TypeSmall organic molecule
Emp. Form.C22H26N6O
Mol. Mass.390.4814
SMILESCOc1ccnc(Nc2cc(nc(n2)-c2ccccc2)N2CC[C@H](C2)N(C)C)c1 |r|
Structure
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