| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM50381307 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814419 (CHEMBL2019815) |
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| IC50 | 38±n/a nM |
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| Citation |  Banerjee, A; Yadav, PS; Bajpai, M; Sangana, RR; Gullapalli, S; Gudi, GS; Gharat, LA Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. Bioorg Med Chem Lett22:3223-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM50381307 |
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| n/a |
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| Name | BDBM50381307 |
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| Synonyms: | CHEMBL2019121 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26N4O3S |
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| Mol. Mass. | 438.543 |
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| SMILES | CNC(=O)[C@@H]1C[C@H]1c1ccc(c(OC)c1)-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1 |r| |
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| Structure | 
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