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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Ligand | BDBM50381315 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_814419 (CHEMBL2019815) | ||
| IC50 | 30±n/a nM | ||
| Citation |  Banerjee, A; Yadav, PS; Bajpai, M; Sangana, RR; Gullapalli, S; Gudi, GS; Gharat, LA Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. Bioorg Med Chem Lett22:3223-8 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | |||
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55514.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13946 | ||
| Residue: | 482 | ||
| Sequence: |
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| BDBM50381315 | |||
| n/a | |||
| Name | BDBM50381315 | ||
| Synonyms: | CHEMBL2019132 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H12F2N4O2S | ||
| Mol. Mass. | 386.375 | ||
| SMILES | COc1cc(N)ccc1-c1nc2snc(-c3c(F)cccc3F)c2c(=O)[nH]1 |(13.71,-27.02,;15.04,-26.25,;16.37,-27.03,;17.7,-26.26,;19.04,-27.03,;20.38,-26.27,;19.04,-28.57,;17.7,-29.34,;16.37,-28.56,;15.04,-29.32,;13.71,-28.55,;12.38,-29.32,;10.91,-28.84,;10,-30.09,;10.91,-31.34,;10.44,-32.8,;8.93,-33.12,;7.9,-31.97,;8.45,-34.58,;9.49,-35.73,;11,-35.4,;11.47,-33.94,;12.8,-34.71,;12.38,-30.86,;13.71,-31.63,;13.71,-33.17,;15.04,-30.86,)| | ||
| Structure | 
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