| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 9 |
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| Ligand | BDBM50187668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814445 (CHEMBL2019841) |
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| Ki | 5630±n/a nM |
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| Citation |  Balboni, G; Congiu, C; Onnis, V; Maresca, A; Scozzafava, A; Winum, JY; Maietti, A; Supuran, CT Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins. Bioorg Med Chem Lett22:3063-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 9 |
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| Name: | Carbonic anhydrase 9 |
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| Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
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| Type: | Enzyme |
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| Mol. Mass.: | 49669.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 459 |
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| Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
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| BDBM50187668 |
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| n/a |
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| Name | BDBM50187668 |
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| Synonyms: | 3-Hydroxyflavone | 3-Hydroxyflavone (12) | 3-hydroxy-2-phenyl-4H-1-benzopyran-4-one | 3-hydroxy-2-phenyl-4H-chromen-4-one | 3-hydroxy-2-phenylchromone | CHEMBL294009 | Flavonol | flavon-3-ol |
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| Type | Small organic molecule |
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| Emp. Form. | C15H10O3 |
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| Mol. Mass. | 238.2381 |
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| SMILES | Oc1c(oc2ccccc2c1=O)-c1ccccc1 |
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| Structure | 
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