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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50381640
Substrate/Competitorn/a
Meas. Tech.ChEMBL_815844 (CHEMBL2026107)
Kd 0.0501±n/a nM
Citation Lainé, DIYan, HXie, HDavis, RSDufour, JWiddowson, KLPalovich, MRWan, ZFoley, JJSchmidt, DBHunsberger, GEBurman, MBacon, AMWebb, EFLuttmann, MASalmon, MSarau, HMUmbrecht, STLandis, PSPeck, BJBusch-Petersen, J Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett22:3366-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M3
Synonyms:ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50381640
n/a
NameBDBM50381640
Synonyms:CHEMBL2023613
TypeSmall organic molecule
Emp. Form.C26H33N2
Mol. Mass.373.5531
SMILESCCC[N+]1(C)C2CCC1C[C@@H](CC(C#N)(c1ccccc1)c1ccccc1)C2 |r,wD:10.11,TLB:4:3:10.9.27:7.6,THB:2:3:10.9.27:7.6,11:10:3:7.6,(34.82,5.42,;34.06,4.08,;34.84,2.75,;34.08,1.42,;32.58,1.82,;35.13,.58,;34.53,-.76,;33.35,-1.47,;34.34,-.12,;36.18,-.12,;37.16,-.93,;37.93,-2.26,;39.47,-2.26,;39.86,-.76,;40.26,.74,;40.25,-3.59,;39.48,-4.92,;40.25,-6.26,;41.79,-6.25,;42.56,-4.91,;41.78,-3.58,;40.95,-1.85,;42.05,-2.94,;43.53,-2.53,;43.92,-1.04,;42.81,.04,;41.34,-.37,;36.89,.61,)|
Structure
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