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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50381645
Substrate/Competitorn/a
Meas. Tech.ChEMBL_815843
IC50 32±n/a nM
Citation Lainé DIYan HXie HDavis RSDufour JWiddowson KLPalovich MRWan ZFoley JJSchmidt DBHunsberger GEBurman MBacon AMWebb EFLuttmann MASalmon MSarau HMUmbrecht STLandis PSPeck BJBusch-Petersen J Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett 22:3366-9 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M1 and M3
Synonyms:CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50381645
n/a
NameBDBM50381645
Synonyms:CHEMBL2023763
TypeSmall organic molecule
Emp. Form.C29H37N2
Mol. Mass.413.6169
SMILESC[N@@+]1(CCCCC=C)C2CCC1C[C@@H](CC(C#N)(c1ccccc1)c1ccccc1)C2 |r,wU:1.0,wD:13.14,1.1,TLB:2:1:13.12.30:10.9,THB:0:1:13.12.30:10.9,14:13:1:10.9,(8.47,.51,;7.71,-.83,;6.21,-.43,;5.82,1.06,;4.33,1.46,;3.94,2.95,;2.45,3.36,;2.06,4.84,;8.76,-1.67,;8.16,-3.01,;6.98,-3.72,;7.97,-2.37,;9.81,-2.37,;10.79,-3.18,;11.56,-4.51,;13.1,-4.51,;13.49,-3.01,;13.89,-1.51,;13.88,-5.84,;13.11,-7.17,;13.88,-8.5,;15.42,-8.5,;16.19,-7.15,;15.41,-5.83,;14.58,-4.1,;15.68,-5.18,;17.16,-4.77,;17.54,-3.29,;16.44,-2.21,;14.96,-2.62,;10.52,-1.63,)|
Structure
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