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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50381907
Substrate/Competitorn/a
Meas. Tech.ChEMBL_817708 (CHEMBL2027356)
EC50 15±n/a nM
Citation Asano, MNakamura, TSekiguchi, YMizuno, YYamaguchi, TTamaki, KShimozato, TDoi-Komuro, HKagari, TTomisato, WInoue, RYuita, HOguchi-Oshima, KKaneko, RNara, FKawase, YMasubuchi, NNakayama, SKoga, TNamba, ENasu, HNishi, T Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists. Bioorg Med Chem Lett22:3083-8 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50381907
n/a
NameBDBM50381907
Synonyms:CHEMBL2022705
TypeSmall organic molecule
Emp. Form.C26H24N2O4S
Mol. Mass.460.545
SMILESCCc1cc(CN2CC(C2)C(O)=O)sc1-c1cc(no1)-c1ccc(Oc2ccccc2)cc1
Structure
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