Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM50381897 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_817708 (CHEMBL2027356) |
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EC50 | 4.1±n/a nM |
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Citation | Asano, M; Nakamura, T; Sekiguchi, Y; Mizuno, Y; Yamaguchi, T; Tamaki, K; Shimozato, T; Doi-Komuro, H; Kagari, T; Tomisato, W; Inoue, R; Yuita, H; Oguchi-Oshima, K; Kaneko, R; Nara, F; Kawase, Y; Masubuchi, N; Nakayama, S; Koga, T; Namba, E; Nasu, H; Nishi, T Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists. Bioorg Med Chem Lett22:3083-8 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM50381897 |
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n/a |
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Name | BDBM50381897 |
Synonyms: | CHEMBL2022916 |
Type | Small organic molecule |
Emp. Form. | C26H31N3O2S |
Mol. Mass. | 449.608 |
SMILES | CCc1nc(CN2CC(C2)C(O)=O)ccc1-c1cnc(s1)-c1ccc(CC(C)C)c(C)c1 |
Structure |
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