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TargetSigma non-opioid intracellular receptor 1
LigandBDBM50382165
Substrate/Competitorn/a
Meas. Tech.ChEMBL_816069 (CHEMBL2026918)
IC50 3.2±n/a nM
Citation Riganas, SPapanastasiou, IFoscolos, GBTsotinis, ABourguignon, JJSerin, GMirjolet, JFDimas, KKourafalos, VNEleutheriades, AMoutsos, VIKhan, HGeorgakopoulou, SZaniou, APrassa, MTheodoropoulou, MPondiki, SVamvakides, A Synthesis,s1,s2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes. Bioorg Med Chem20:3323-31 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sigma non-opioid intracellular receptor 1
Name:Sigma non-opioid intracellular receptor 1
Synonyms:Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:Enzyme Catalytic Domain
Mol. Mass.:25124.85
Organism:Homo sapiens (Human)
Description:Q99720
Residue:223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50382165
n/a
NameBDBM50382165
Synonyms:CHEMBL2023823
TypeSmall organic molecule
Emp. Form.C28H36N2
Mol. Mass.400.5988
SMILESCN1CCN(CC1)c1ccc(cc1)C(c1ccccc1)C12CC3CC(CC(C3)C1)C2 |TLB:13:20:23.22.27:25,THB:21:22:25:29.20.28,21:20:23.22.27:25,28:20:23:27.26.25,28:26:23:29.21.20,13:20:23:27.26.25|
Structure
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